Organoids

 


A new research article was published in the journal Nature Communication. A group of scientists invented a platform that creates uniform production of organoids that mimic biology.

Organoids are a cell like material that replicate the functions of human organs. The heterogeneity and low reproducibility of organoids prevent them from being scaled up into production. The team created a platform called UniMat (Uniform and Mature Organoid Culture Platform). This platform enables the production of mature organoids.

A 3D engineered membrane made of fine nano fibers provided a structured framework for organoid formation. Nutrient and differentiation factors were enhanced, both crucial for organoid maturation.

Professor Kim is from POSTECH (Pohang University of Science and Technology). He led the research. He summarizes, "Though these research outcomes, we not only accelerate organoid- based R and D that requires high reproducibility and reliability but we also expect to make significant contributions to the development of animal alternative testing methods, which are gaining increasing attention. By addressing both the quality assurance and scalable production challenges of organoids with UniMat, we have laid the foundation for the practical application of organoids in clinical and pharmaceutical industries."


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