Supranormal Hearing in Mice and Men Heartsound Audio

 


A new study from Michigan Medicine’s Kresge Hearing Research Institute showed supranormal Hearing in mice, while supporting an idea about the case of hidden hearing loss in humans. 

Researchers used similar methods as previous tests by increasing the amount of neurotrophic factor in the inner ear. This promotes the recovery of auditory responses In mice that previously experienced auditory trauma and improved hearing in middle-aged mice.

This is the first study to use the same techniques in otherwise young mice to create improved  auditory processing.

“ We knew that providing NTF3’s To the inner ear in young mice increased the number of synapses between inner hair cells and auditory neurons, but we did not know what having more synapses would do to hearing” said Gabriel Corfas director of Kresge Institute. 

The research shows that animals with extra hairs in their ears have normal hearing, but can process the sound in supranormal ways. Inner Hair cells exist inside the cochlea and convert sound waves into signals sent via synapses to the brain. 

In this new experiment, two groups of mice were studied. One in which synapses were reduced and a second.- The supranormal Hearing mice where the synapses were increased. 

“ Previously, we have used the same molecule to regenerate synapses due to noise and exposure in young mice, and to improve hearing in middle-aged mice, when they already starting to show signs of age related hearing loss.” Reports  Corfas. 

These experiments suggest that the molecule has the potential to improve hearing in humans in similar situations. The new results indicate the regenerating synapses or  increasing their numbers will improve auditory processing in humans.

Hair loss had once been believed to be the number one cause of hearing loss in humans as we age. Now it’s understood that the loss of inner hair synapses can be the first event in the hearing loss process. Creating therapies that preserve, regenerate, and/or Increase synapses are some exciting new possibilities for people with hearing disorders.

Hugs,

Krissy 

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